Prof. Dr. Oschkinat, Dr. Freund:

Multivalent protein-protein interactions between WW domains and proline-rich segments

Multivalency constitutes a commonly used strategy to enhance local concentrations of interacting macromolecules. Within the cell, this principle might serve in the clustering of low-affine protein:protein interactions, e.g. for the purpose of signal transduction. In project C4 small protein adaptor domains, so-called WW domains and their interaction with proline-rich sequences are investigated. We want to understand in how far multivalency contributes to the dynamic assembly of spliceosomal protein complexes. NMR spectroscopic experiments in conjunction with biochemical and proteomic analyses should delineate the mechanistic and functional implications of WW domain mediated multivalency.

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