research topics

 

 
The actual research topics of our group are:

 
    Development of highly potent, protease stable peptide inhibitors targeted to the gp41 region of HIV-1
 
Evaluation of the potential of fluoroalkyl substituted amino acids for peptide and protein modification using phage display
 
Koksch research in this area was highlighted in

"Fluorine rises to the occasion. From pharmaceuticals to high-tech materials, conference spotlights expanding role of fluorine" Stephen K. Ritter , Chem. & Eng. News. 2005, 14.02.05, 35-40, http://www.cen-online.org.
 
Design of peptide sequences, which can be induced to undergo a defined alpha-beta structural transition based on environmental factors
 
Development of new methods for the protease catalyzed incorporation of non-natural amino acids into peptides
 
Study of peptide-membrane-interaction using 19F NMR label
   

Peptide coupling of fluorinated amino acids by microwave assisted synthetic methods

(Peptidkupplung zum Einbau fluorierter Aminosäuren mittels mikrowellen-unterstützter Synthesemethoden)