Dr. Corinna Lippmann
Thielallee 63, 14195 Berlin; Tel. +49 30 838-6402 / 56003, Fax -56403;
E-mail:
pollux@chemie.fu-berlin.de
Keywords: Protein biosynthesis, posttranslational modifications,
protein-RNA interactions.
(Beitrag aus der Fachbereichsbroschüre des FB Chemie von 1996)
Forschungsgebiete
Corinna Lippmann, a postdoc of Prof. V. A. Erdmann's group, has focused
her interest on posttranslational modifications in prokaryotes. She described
for the first time phosphorylation of elongation factor Tu at a strictly
conserved position, threonine 382 in E.coli. Several experimental
results indicate that the modification is part of the elongation cycle
in protein biosynthesis. Introduction of a phosphate group leads to the
switch of a condensed (GTP-complexed) formation to the more open GDP form.
The structure of EF-Tu is known at high resolution since Corinna Lippmann
first succeeded in growing crystals from the intact protein suitable for
X-ray analysis. Dr. Lippmann is also involved in a trilateral project between
Israel, the Palestinian Authority and Germany, initiated and coordinated
by Prof. V. A. Erdmann concerned with tumour diagnosis and therapy based
on oncofetal RNAs. The working group consists of two Ph.D. and one master
student. Postdocs from other European countries often join Dr. Lippmann's
group. The studies on the EF-Tu project are supported by the DFG (Li 611
1/2) and the European Community.
© 1996, Redaktionsschluß: 1996-08-01.