Joint Meeting 

of the International Society for Neurochemistry (ISN)
and the European Society for Neurochemistry (ESN),
to be held in Berlin, Germany from August 8 - 14, 1999

_____________________________________________

Detailed program of the Symposia and Young Investgators Colloquia

Symposium 1
REGULATION OF CELL LINEAGE

3
Guillemot, F., Casarosa, S., Fode, C., Parras, C.
NEURAL DETERMINATION GENES IN NEUROGENESIS AND DORSAL-VENTRAL PATTERNING OF THE MOUSE FOREBRAIN

4
McKay, R.
STEM CELL DIFFERENTIATION AND SYNAPSE ACTIVATION IN THE CNS.

5
Bartlett, P. F., Polizzotto, M. N., Faux, C. H., Turnley, A. M.
REGULATION OF NEURAL STEM CELL DIFFERENTIATION BY INHIBITING CYTOKINE AND NOTCH SIGNALLING

6
Kessler, J. A., Mehler, M. F., Mabie, P. C., Gomes, W., Zhang, D., Zhu, G.
DEVELOPMENTAL CHANGES IN PROGENITOR CELL POTENTIAL AND RESPONSES TO BMPS
 
 

Symposium 2
DISEASES ASSOCIATED WITH ION CHANNELS

7
Barhanin, J., Chouabe, C., Drici, M.D., Guicheny, P., Neyroud, N., Romey, G., Lazdunski, M.
KCNQ1 AND ISK MUTATIONS IN LQTS

8
van den Maagdenberg, A.M.
MIGRAINE AND ATAXIA: EPISODIC AND CHRONIC FEATURES OF NEURONAL CACNA1A CHANNELOPATHIES

9
Jentsch, T.
DISEASES DUE TO KCNQ POTASSIUM CHANNEL MUTATIONS: EPILEPSY AND DEAFNESS

10
Tempel, B.
CONTROLING HYPERACTIVITY, THE ROLE OF KV1.1 POTASSIUM CHANNELS
 
 

Symposium 3
PROTEINS ASSOCIATED WITH SYNAPTIC VESICLES/TRANSMITTER RELEASE MECHANISMS

11
Scheller, R. H.
SNARE COMPLEX FORMATION IS TRIGGERED BY CA 2+ AND DRIVES MEMBRANE FUSION

12
Martin, Thomas F. J.
LATE STAGES OF DENSE-CORE VESICLE EXOCYTOSIS

13
Augustine, G.
MOLECULAR MECHANISMS OF NEUROTRANSMITTER RELEASE

14
De Camilli, P.
MOLECULAR MECHANISMS IN SYNAPTIC ENDOCYTOSIS
 
 

Symposium 4
MOLECULAR MECHANISMS OF NEURITE EXTENTION AND GROWTH CONE FORMATION

204
Jay, D.G., Takei, K., Hoffmann-Kim, D.
ADDRESSING A LINK BETWEEN NEURAL CELL ADHESION MOLECULE L1 PP60-C-SCR DURING NEURITE OUTGROWTH

205
Bolsover, S.
CALCIUM SIGNALLING DURING AXOGENESIS AND PATHFINDING

206
Mikoshiba, K., Takei, K., Fukada, M., Kabayama, H., Ibata, K., Shin, R.-M., Inoue, T., Kato, K.
ROLE OF CA 2+ SIGNALING IN NEURITE EXTENSION AND GROWTH CONE FORMATION

207
Spira, M.E., Oren, Prager, Gitler
DEDIFFERENTIATION OF ADULT AXON INTO A MOTILE GROWTH CONE: THE ROLE OF CALCIUM, CALPAIN,  SPECTRIN AND MEMBRANE CYCLING
 
 

Symposium 5
MOLECULAR AND CELLULAR ASPECTS OF ALZHEIMER'S DISEASE

208
Hartmann, T., Beyreuther, K., Masters, C.L.
PHYSIOLOGICAL AND PATHOGENETIC FUNCTION OF APP AND ITS AMYLOID DOMAIN

209
Goedert, M.
INTRANEURONAL FILAMENTOUS DEPOSITS IN ALZHEIMER'S DISEASE AND RELATED DEMENTIAS

210
St George-Hyslop, P.
GENETICS OF ALZHEIMER'S DISEASE

211
Roses, A. D.
ALZHEIMER DISEASE AND THE RELEVANCE OF APO-E ISOFORM-SPECIFIC METABOLISM
 
 

Symposium 6
GABA-A RECEPTOR SUBUNIT KNOCKOUT MICE: INSIGHTS INTO FUNCTION AND RELEVANCE TO HUMAN DISEASES

212
Olsen, R., DeLorey, T.M., Handforth, A., Homanics, G.E.
EPILEPSY IN GABA-A RECEPTOR SUBUNIT KNOCKOUT MICE

213
Möhler, H., Fritschy, J.-M., Benke, D., Rudolph, U., Lüscher, B., Crestani, F.
GENE-TARGETED APPROACHES TO ANXIETY DISORDERS AND THEIR THERAPY

214
Wisden, W.
WHY SO MANY GABA-A RECEPTOR SUBTYPES? CLUES FROM CEREBELLAR GRANULE CELLS

215
Homanics, G.E., Mihalek, R.M., Firestone, L.L., Quinlan, J.J.
ALCOHOL AND ANESTHETIC MECHANISMS IN GABA-A RECEPTOR GENE KNOCKOUT MICE
 

Symposium 7
MOLECULAR MECHANISMS OF SYNAPTIC DEVELOPMENT AND PLASTICITY

408
Kins, S.
MOLECULAR MECHANISMS UNDERLYING THE FORMATION OF GLYCINERGIC SYNAPSES

409
Worley, P.
HOMER SIGNALING COMPLEX LINKS GROUP 1 METABOTROPIC AND IP3 RECEPTORS

410
Gundelfinger, E. D.
NOVEL SYNAPTIC PROTEINS AND THEIR ROLE IN THE ASSEMBLY AND FUNCTION OF CNS SYNAPSES

411
Sheng, M.
THE MOLECULAR ORGANIZATION OF THE POSTSYNAPTIC MEMBRANE IN EXCITATORY SYNAPSES
 
 

Symposium 8
MODULATION OF ION CHANNELS

412
Dolphin, A.C.
STRUCTURE-FUNCTION STUDIES ON EXPRESSION AND G PROTEIN MODULATION OF VOLTAGE-DEPENDENT CALCIUM CHANNELS

413
Catterall, W.A.
MOLECULAR MECHANISMS OF SODIUM CHANNEL MODULATION

414
Ascher, P.
PHYSIOLOGICAL MODULATIONS OF THE NMDA RECEPTORS

415
Reinhart, P.
POTASSIUM CHANNEL MODULATION BY CA2+ AND PROTEIN KINASES
 

Symposium 9
NEW THERAPEUTIC APPROACHES TO CNS REPAIR

416
Tuszynski, M.H., Grill, R., Blesch, A., Weidner, N.
NEUROTROPHIC FACTOR GENE THERAPY FOR SPINAL CORD INJURY

417
Müller, H.W., Stichel, C.C.
LESION-INDUCED BASAL LAMINA AS A MAJOR BARRIER TO AXONAL REGENERATION IN THE ADULT CNS: GETTING ACROSS

418
Schwab, M.E.
STRUCTURAL PLASTICITY, AXONAL GROWTH AND FUNCTIONAL RESTORATION IN THE ADULT CNS FOLLOWING LESIONS

419
Raisman, G.
FUNCTIONAL AND STRUCTURAL RECONSTRUCTION OF THE ADULT RAT CORTICOSPINAL TRACT BY MEANS OF TRANSPLANTED OLFACTORY ENSHEATHING CELLS.
 
 

Symposium 10
NEURONAL POLARITY AND SYNAPSE FORMATION

422
Triller, A., Lévi, S., Vannier, C., Meier, J.
PRESYNAPTIC INNERVATION AND ACCUMULATION OF GLYCINE RECEPTORS AT CENTRAL SYNAPSES

423
Craig, A.M., Stowell, J.N., Rao, A., Allison, D.W.
GLUTAMATE RECEPTOR TARGETING AND ASSEMBLY OF EXCITATORY SYNAPSES

424
Cartaud, J.
TARGETING OF ACETYLCHOLINE RECEPTOR AND 43KDA-RAPSYN TO THE POSTSYNAPTIC MEMBRANE IN TORPEDO MARMORATA ELECTROCYTE

425
Buckley, K.M., Melikian, H.E.
REGULATION OF TRANSPORTER FUNCTION BY PROTEIN TRAFFICKING
 
 

Symposium 11
MICROGLIA IN BRAIN DISEASE

426
Raivich, G.
MOLECULAR SIGNALS IN MICROGLIAL ACTIVATION

427
Benveniste, E., Nguyen, V., O`Keefe, G.
REGULATION AND FUNCTION OF CLASS II MHC AND CD40 GENES IN MICROGLIA

428
Kretzschmar, H.
ROLE OF MICROGLIA IN PRION-DISEASE

429
Patterson, Paul
THE ROLE OF LIF IN NEUROIMMUNE INTERACTIONS
 

Symposium 12
Schering-Symposium
SIGNALING MECHANISAMS IN NEURONAL SURVIVAL

430
Hemmings, B.A.
SIGNAL TRANSDUCTION BY LIPID SECOND MESSENGERS – BASIC MECHANISMS

431
Tolkovsky, A.M., Anderson, C.N.G., Sampson, C.B.P., Virdee, K., Xue, L.
USE OF MUTLITPLE SIGNALLING PATHWAYS IS CRUCIAL FOR SUPPRESSING NEURONAL APOPTOSIS
 

432
Ham, J., Eilers, A., Whitfield, J. Shah, B., Neame, S.
C-JUN AND THE SIGNALING OF CELL DEATH IN NEURONS

433
Kaplan, D.
NEUROTROPHIN SIGNAL TRANSDUCTION IN THE SURVIVAL OF NEURONS AND NEURAL TUMOR CELLS
 
 

Symposium 13
TRIGGERS OF NEURONAL CELL DEATH

637
Driscoll, M.
MOLECULAR MECHANISMS OF NECROTIC-LIKE CELL DEATH IN C. ELEGANS

638
Nicotera, P.
EXCITOTOXIC LOOPS AND NEURONAL APOPTOSIS

639
Mattson, M.P., Guo, Q., Duan, W., Chan, S.L.
ROLES OF PAR-4 AND CASPASES IN "SYNAPTIC APOPTOSIS" AND REMODELING
 
 

Symposium 14
SIGNALING BY PHOSPHORYLATION TARGETED TO THE CELL NUCLEUS

643
Buchner, K.
PKC SIGNALING INTO THE CELL NUCLEUS

640
Deisseroth, K., Wu, G., Mermelstein, P.G., Pitt, S., Zühlke, R., Reuter, H., Tsien, R.W.
COMMUNICATION BETWEEN SYNAPSE AND NUCLEUS

641
Sweatt, J.D., Robertson, E.D., English, J.D., Adams, J.P., Selcher, J.C., Atkins, C.
THE MITOGEN-ACTIVATED PROTEIN KINASE CASCADE COUPLES PKA AND PKC TO CREB PHOSPHORYKATION IN AREA CA1 OF HIPPOCAMPUS

642
Sassone-Corsi, P.   LECTURE CANCELLED
TRANSCRIPTION MECHANISMS COUPLED TO cAMP SIGNALING
 

Symposium 15
NEUROCHEMISTRY OF OLFACTION

644
Breer, H., Strotmann, J., Beck, A., Conzelmann, S., Mombaerts, P., Feinstein, P.
OLFACTORY RECEPTORS: EXPRESSION PATTERNS AND TOPOGRAPHIC PROJECTIONS

645
Zufall, F.
MECHANISM OF ODOR ADAPTATION IN OLFACTORY NEURONS

646
Firestein, S., Araneda, R., Kini, A.
PHARMACOLOGY OF ODOR RECEPTORS

647
Mori, N., Yoshihara, Y., Nagao, N., von Camphausen, H.
OCAM AND ZONAL ORGANIZATION OF MAMMALIAN MAIN AND ACCESSORY OLFACTORY SYSTEMS
 
 

Symposium 16
REGULATION OF MYELIN GENE EXPRESSION IN MYELIN FORMING CELLS AND NON-MYELINATING CELLS

648
Zalc, B., Spassky, N., Olivier, C., Goujet-Zalc, C., Perez-Villegas, E., Poncet, C., Cochard, P., Martinez, S.,
Thomas, J.-L.
EARLY EXPRESSION OF PLP DURING EMBRYONIC DEVELOPMENT OF AMNIOTS AS A MARKER OF OLIGODENDROGENESIS

649
Casaccia-Bonnefil, P., Hardy, R., Levine, J., Chao, M.V.
MECHANISMS OF REGULATION OF OLIGODENDROCYTE CELL NUMBER

650
Campagnoni, A.
REGULATION OF MYELIN PROTEIN GENE-EXPRESSION IN NEURONS AND IN THE IMMUNE SYSTEM

651
Scherer, S.S., Bone, L.J., Deschenes, S.M., Abel, A., Balice-Gordon, R.J.
THE ROLE OF THE GAP JUNCTION PROTEIN CONNEXIN32 IN THE MYELIN SHEATH
 
 

Colloquium 1
NEURONAL ACTIVITY & PLASTICITY

15
Caroll, R. C., Lissin, D. V., Zastrow, M. v., Nicoll, R. A., Malenka, R. C.
SILENT SYNAPSES AND SYNAPTIC PLASTICITY

16
Goda, Y., Hagler, D. J.
ACTIVITY-DEPENDENT LONG-TERM DEPRESSION AND SYNAPSE SILENCING

17
Spruston, N.
DENDRITIC EXCITABILITY IN HIPPOCAMPAL CA1 PYRAMIDAL NEURONS

18
Eilers, J.
HIGH-RESOLUTION CALCIUM IMAGING IN LIVING NEURONS
 
 

Colloquim 2
NEURO-GLIAL INTERACTIONS OF THE NODE OF RANVIER

19
Baba, H.
MOLECULAR MECHANISMS FOR K+ CHANNEL CLUSTERING ON MYELINATED AXONS

20
Rasband, M.
SCHWANN CELL MEDIATED K+ CHANNEL CLUSTERING AND REDISTRIBUTION DURING REMYELINATION

21
Peles, E., Gollan, L., Poliak, S.
MOLECULAR MECHANISMS OF CASPR LOCALIZATION TO THE PARANODES OF RANVIER

22
Lambert, S., Zhou, D., Malen, P.L., Walker, B., Carpenter, S., Boland, L.M., Bennett, V.
ANKYRING AND THE LOCALIZATION OF SODIUM CHANNELS IN THE AXONAL MEMBRANE
 
 

Colloquium 3
NEUROTRANSMITTER TRANSPORTERS

23
Gasnier, B., Dumoulin, A., Rostaing, P., Bedet, C., Lévi, S., Isambert, M.-F., Henry, J.-P., Triller, A.
PRESENCE OF THE VESICULAR INHIBITORY AMINO ACID TRANSPORTER IN GABAERGIC AND GLYCINERIC SYNAPTIC TERMINAL BOUTONS

24
Quick, M. W., Bernstein, E., Beckman, M. L.
FUNCTIONAL REGULATION OF GABA TRANSPORTERS

25
Zafra, F.
MOLECULAR CHARACTERIZATION OF THE GLYCINE TRANSPORTERS

26
Kavanaugh, M. P.
GLUTAMATE TRANSPORTERS IN BRAIN: NEW COMPLEXITIES IN STRUCTURE AND FUNCTION
 
 

Colloquium 4
NEUROTRANSMITTER RECEPTORS

216
Hoch, W., Hopf, C., Bayer, M.
AGRIN-INDUCED DIMERIZATION OF THE MUSCLE-SPECIFIC KINASE INITIATES THE AGGREGATION OF ACETYLCHOLINE RECEPTOR

217
Rubinstein, M., Gelman, D., Falzone, T., Kelly, M., Phillips, T., Dickinson, S., Zahniser, N., Grandy, D., Low, M.
CONDITIONAL GENE TARGETING OF BRAIN DOPAMINE D2 RECEPTORS

218
Kirchhoff, F., Matyash, M., Matyash, V.
CONDITIONAL TARGETING OF THE GLUTAMATE RECEPTOR SUBUNIT GLUR B INTO GLIAL CELLS

219
Coco, S., Matteoli, M., Bacci, A., Verderio, C.
GLUTAMATE RECEPTORS AND TRANSPORTERS IN SYNAPTIC DEVELOPMENT AND FUNCTIONALITY
 
 

Colloquium 5
GENES AND DEVELOPMENT

220
Verdi, J., Kabu, C., Goldhawk, D., Meakin, S.O., Mcdonald, J.
INTRINSIC AND EXTRINSIC FACTORS GOVERNING SYMPATHETIC NEUROGENESIS

221
Arber, S., Lin, J., Ladle, D., Frank, E., Jessell, T.M.
ETS GENE FUNCTION IN THE FORMATION OF SPINAL REFLEX CIRCUITS

222
Brunet, J.-F., Pattyn, A., Pujol, N., Morin, X., Cremer, H., Goridis, C.
TRANSCRIPTIONAL CONSTRUCTION OF NEURONAL IDENTITIES: STUDIES ON THE HOMEODOMAIN PROTEINS PHOX2

223
Piccolo, S.
MOLECULAR MECHANISMS OF FOREBRAIN INDUCTION:THE ROLE OF CERBERUS PROTEIN
 
 

Colloquium 6
NEURONAL CELL DEATH

224
Dawson, V.L.
MECHANISMS OF SENSITIVITY AND RESISTANCE TO NEURONAL EXCITOTOXICITY

225
Frade, J.
CELL DEATH ASSOCIATED TO NEUROGENESIS IN THE CHICK RETINA: POSITIVE AND NEGATIVE MODULATION BY NEUROTROPHINS

226
Schulz, J.
CASPASES AS TREATMENT TARGETS FOR NEURO-DEGENERATIVE DISEASES

227
Robertson, G.
CASPASE-3 INHIBITION BY THE IAPS PREVENTS BOTH CELLULAR AND BEHAVIOURAL DEFICITS FOLLOWING TRANSIENT FOREBRAIN ISCHEMIA
 
 

Colloquium 7
ROLES OF NEUROTROPHIC FACTORS BEYOND CELL SURVIVAL

434
Fainzilber, M., Brann, A.B., Scott, R., Neuberger, Y., Boldin, S., Futerman, A.H.
NEUROTROPHIC FACTORS IN NEURONAL OUTGROWTH AND REMODELLING OF THE NERVOUS SYSTEM

435
Birren, S.J., Lockhart, S.T., Mead, J.N.
REGULATION OF SYMPATHETIC SYNAPSE FORMATION BY NERVE GROWTH FACTOR AND MYOCYTE-DERIVED FACTORS

436
Schnuerch, H., Friedel, R., Stubbusch, J., Lindemann, L., Barde, Y.
IDENTIFICATION OF GENES DIFFERENTIALLY EXPRESSED BY NGF- AND NT3-DEPENDENT SENSORY NEURONS

437
Lessmann, V., Haubensak, W., Hartmann, M., Narz, F., Erdmann, K., Klau, M., Salmen, B., Heumann, R.
NEUROTROPHINS AS ENDOGENOUS MEDIATORS OF SYNAPTIC PLASTICITY
 
 

Colloquium 8
FUNCTIONS OF INTEGRINS AND IG-SUPERFAMILY MEMBERS DURING NERVOUS SYSTEM DEVELOPMENT AND IN THE ADULT

438
Brümmendorf, T., Marg, A., De Angelis, E., Sirim, P., Plagge, A., MacFarlane, J., Yeo, G., Spaltman, F., Kauselmann, G., Buck, F., Kenwrick, S., Rathjen, F.G.
IG SUPERFAMILY MOLECULES IN NEUROHISTOGENESIS: FROM THE ANALYSIS OF AXON ELONGATION TO HEREDITARY MALFORMATIONS OF AXON TRACTS

439
Cremer, H., Chazal, G., Lledo, P.M., Rougon, G.
FUNCTION OF NEURAL CELL ADHESION MOLECULE (NCAM) IN PLASTIC PROCESSES IN THE ADULT NERVOUS SYSTEM

440
Müller, U., Littlewood-Evans, A.
INTEGRIN FUNCTIONS IN INNER EAR DEVELOPMENT

441
Stoeckli, E.T., Perrin, F.E., Burstyn-Cohen, T., Rathjen, F.G., Klar, A.
MOLECULAR MECHANISMS OF COMMISSURAL AXON GUIDANCE
 
 

Colloquium 9
SIGNAL TRANSDUCTION

442
Brambilla, R.
RAS/MAPK SIGNALING IN NEURONAL PLASTICITY AND BEHAVIOR

443
Chen, C.
MODULATION OF DIFFERENT ION CHANNELS BY SOMATOSTATIN THROUGH SEVERAL SUBTYPES OF G-PROTEINS : STUDIES USING INTRACELLULAR DIALYSIS OF ANTIBODIES AND ANTISENSE OLIGONUCLEOTIDES

444
Haavik, J., Thomas, G., Toska, K.
REGULATION OF TYROSINE HYDROXYLASE BY STRESS-ACTIVATED PROTEIN KINASE PATHWAYS

445
Seger, R., Benard, O., Naor, Z.
MECHANISMS OF MAP KINASE ACTIVATION BY GNRH
 
 

Colloquium 10
MODULATION OF NEURONAL ACTIVITY BY ASTROCYTE

652
Pfrieger, F.W., Nägler, K., Mauch, D.
GLIAL SIGNALS REGULATE AUTAPSE FORMATION IN CNS NEURONS

653
Nakamura, T., Kudo, Y.
OPTICAL DETECTION OF SYNAPTICALLY INDUCED GLUTAMATE TRANSPORT IN HIPPOCAMPAL SLICES

654
Bergles, D.E., Jahr, C.E.
SYNAPTIC ACTIVATION OF GLUTAMATE TRANSPORTERS IN HIPPOCAMPAL ASTROCYTES

655
Volterra, A.
AN INTEGRATED NEURON-GLIA DIALOGUE IN THE PROCESSING OF BRAIN INFORMATION
 
 

Colloquium 11
ANCHORING OF RECEPTORS AND TRANSPORTERS TO THE CYTOSKELETON

656
Thomas, U., Koh, Y.-H., Ebitsch, S., Garner, C.C., Budnik, V., Gundelfinger, E.D.
FUNCTION AND REGULATION OF DLG/SAP90-LIKE MEMBRANE ASSOCIATED GUANYLATE KINASES AT A GLUTAMATERGIC MODEL SYNAPSE

657
Kupper, J., Fromherz, P.
FUNCTIONAL EXPRESSION OF GFP-KV CHANNELS AND PSD-95-YFP IN HIPPOCAMPAL NEURONS

658
Moss, S.J., Bedford, F.K., Brandon, N.J., Connolly, C.N., Kittler, J.T., Hanley, J.G., Jovanovic, J., Uren, J.
MECHANISMS UNDERLYING THE SUBCELLULAR LOCALISATION OF IONOTROPIC GABA RECEPTORS

659
Marshall, J.
DIFFERENTIAL INTERACTION OF SYNAPSE ASSOCIATED PROTEINS WITH KAINATE RECEPTORS
 
 

Colloquium 12
SIGNIFICANCE OF SUGAR CHAINS IN CELL-CELL INTERACTION

660
Tiemeyer, M., Seppo, A., Matani, P., Sharrow, M., Andrejeva, L., Parisky, K.
CELL SURFACE CARBOHYDRATES AND ENDOGENOUS LECTINS IN THE DROSOPHILA NERVOUS SYSTEM

661
Popko, B.
GALACTOLIPIDS IN MYELIN FORMATION AND FUNCTION

662
Hitoshi, S., Kusunoki, S., Kanazawa, I., Tsuji, S.
THE EXPRESSION OF CARBOHYDRATE ANTIGENS ON DORSAL ROOT GANGLIA NEURONS; REGULATORY MECHANISMS AND BIOLOGICAL FUNCTIONS

663
Yoshimura, M., Taniguchi, N.
MODULATION OF OLIGOSACCHARIDES THROUGH A GLCNAC-TRANSFERASE III GENE TRANSFECTION ENHANCES E-CADHERIN-MEDIATED CELL ADHESION AND SUPPRESSES NGF-MEDIATED NEURAL CELL DIFFERENTIATION

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