ÿþ<HTML> <HEAD> <title>Knaus Lab - Institut für Chemie - Biochemie - FU Berlin</title> <meta name="description" content="Knaus Lab Homepage, Prof. Dr. Petra Knaus, Freie Universität Berlin, Germany"> <meta name="keywords" content="prof. dr. petra knaus, institut für biochemie, biochemistry, freie universität berlin, university, bone morphogenetic proteins, bmp, transforming growth factor ß, tgf-ß, growth and differentiation factors, gdf, orphan receptor tyrosin kinase 2, ror2, smad, co-smad, activin, inhibin, müllerian-inhibiting substance, drosophila embryogenesis, decapentaplegic, dpp, morphogen gradient"> <LINK REL="Shortcut Icon" HREF="images/knauslab.ico"></LINK> </HEAD> <BODY LEFTMARGIN="0" TOPMARGIN="0" MARGINWIDTH="0" MARGINHEIGHT="0"> <center> <!-- TABLE BEGINS --> <TABLE style="background-image: url(images/Design07-03xx_5.jpg)" CELLPADDING="0" CELLSPACING="0" BORDER="0"> <TR> <!-- KNAUS LAB LOGO OBEN LINKS --> <TD valign=top><IMG WIDTH="166" HEIGHT="125" SRC="images/Design07-03_1.jpg" BORDER="0"></TD> <!-- HEADER --> <TD valign=top><IMG WIDTH="616" HEIGHT="125" SRC="images/Design07-03_2.jpg" USEMAP="#Map1" BORDER="0"></TD> </TR> <TR> <!-- SIDEBAR --> <TD valign=top ROWSPAN="2"> <IMG valign=top WIDTH="166" HEIGHT="380" SRC="images/Design07-03_3.jpg" USEMAP="#Map2" BORDER="0"> </TD> <!-- KOPF TEXTFELD --> <TD valign=top><IMG valign=top WIDTH="616" SRC="images/Design07-03_4.jpg" BORDER="0"></TD> </TR> <TR valign=top> <!-- ****TEXTFELD = INHALT**** --> <TD valign=top width=616> <p style="margin-right:0.7cm;margin-left:0.7cm" align="justify"> Most of the following publication abstracts are available through <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed" target="_blank">PubMed</a> or the respective Journal. However, you may need a valid registration in order to download the full article.<br><br> <b>[2011]</b> <br><br>Horbelt D, Denkis A, Knaus P.<br> <b>A portrait of Transforming Growth Factor ² superfamily signalling: Background matters. </b><br><u><a href=http://www.ncbi.nlm.nih.gov/pubmed/22226817> Int J Biochem Cell Biol.</a></u>2011 Dec 31. [Epub ahead of print] <br><br>Pohl TL, Boergermann JH, Schwaerzer GK, Knaus P, Cavalcanti-Adam EA. <br> <b>Surface immobilization of bone morphogenetic protein 2 via a self-assembled monolayer formation induces cell differentiation.</b><br><u><a href=http://www.ncbi.nlm.nih.gov/pubmed/22040684> Acta Biomater.</a></u>2012 Feb;8(2):772-80. Epub 2011 Oct 20 <br><br>Heining E, Bhushan R, Paarmann P, Henis YI, Knaus P. <br> <b>Spatial segregation of BMP/Smad signaling affects osteoblast differentiation in C2C12 cells.</b><br><u><a href=http://www.ncbi.nlm.nih.gov/pubmed/21998639> PLoS One.</a></u>2011 2011;6(10):e25163. Epub 2011 Oct 5. <br><br>Schwaerzer GK, Hiepen C, Schrewe H, Nickel J, Ploeger F, Sebald W, Mueller T, Knaus P. <br> <b>New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): Mutation within the GDF5 knuckle epitope causes noggin-resistance.</b><br><u><a href=http://www.ncbi.nlm.nih.gov/pubmed/21976273> J Bone Miner Res.</a></u>2011 Oct 4. doi: 10.1002/jbmr.532. [Epub ahead of print]. <br><br>Lange C, Li C, Manjubala I, Wagermaier W, Kühnisch J, Kolanczyk M, Mundlos S, Knaus P, Fratzl P. <br> <b>Fetal and postnatal mouse bone tissue contains more calcium than is present in hydroxyapatite.</b><br><u><a href=http://www.ncbi.nlm.nih.gov/pubmed/21855638> J Struct Biol.</a></u>2011 Nov;176(2):159-67. Epub 2011 Aug 10. <br><br>Poorgholi Belverdi M, Krause C, Guzman A, Knaus P. <br> <b>Comprehensive analysis of TGF-² and BMP receptor interactomes. </b><br><u><a href=http://www.ncbi.nlm.nih.gov/pubmed/21715044> Eur J Cell Biol.</a></u>2011 Jun 27. Epub ahead of print. <br><br>Ehrlich M, Horbelt D, Marom B, Knaus P, Henis YI. <br> <b>Homomeric and heteromeric complexes among TGF-² and BMP receptors and their roles in signaling.</b><br><u><a href=http://www.ncbi.nlm.nih.gov/pubmed/21515362> Cell Signal.</a></u>2011 Sep;23(9):1424-32 Epub ahead of print. <br><br>Marom B, Heining E, Knaus P, Henis YI. <br> <b>Formation of stable homomeric and transient heteromeric BMP receptor complexes regulates Smad signaling.</b><br><u><a href=http://www.ncbi.nlm.nih.gov/pubmed/21471205> J Biol Chem.</a></u>2011 Apr 6 Epub ahead of print. <br><br>Ott CE, Grünhagen J, Jäger M, Horbelt D, Schwill S, Kallenbach K, Guo G, Manke T, Knaus P, Mundlos S, Robinson PN. <br> <b>MicroRNAs differentially expressed in postnatal aortic development downregulate elastin via 3' UTR and coding-sequence binding sites.</b><br><u><a href=http://www.ncbi.nlm.nih.gov/pubmed/21305018> PLoS One.</a></u>2011 Jan 31;6(1):e16250. <br><br>Krause C, Guzman A, Knaus P. <br> <b>Noggin</b><br><u><a href=http:http://www.ncbi.nlm.nih.gov/pubmed/21256973> Int J Biochem Cell Biol.</a></u>2011 Apr;43(4):478-81. Epub 2011 Jan 21 <br><br> <b>[2010]</b> <!-- <br><br>Authors<br> <b>Titel</b><br> <u><a href=URLHERE>Journal</a></u> dates --> <br><br>Horbelt D, Guo G, Robinson PN, Knaus P. <br> <b>Quantitative analysis of TGFBR2 mutations in Marfan-syndrome-related disorders suggests a correlation between phenotypic severity and Smad signaling activity</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/pubmed/21098638>J Cell Sci.</a></u> 2010 Dec 15;123(Pt 24):4340-50. <br><br>Zelman-Femiak M, Wang K, Gromova KV, Knaus P, Harms GS. <br> <b>Covalent quantum dot receptor linkage via the acyl carrier protein for single-molecule tracking, internalization, and trafficking studies</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/pubmed/20701592>Biotechniques.</a></u> 2010 Aug;49(2):574-9. <br><br>Boergermann JH, Kopf J, Yu PB, Knaus P. <br> <b>Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/pubmed/20691279>Int J Biochem Cell Biol.</a></u> 2010 Nov;42(11):1802-7. <br><br>Glaeser JD, Geissler S, Ode A, Schipp CJ, Matziolis G, Taylor WR, Knaus P, Perka C, Duda GN, Kasper G. <br> <b>Modulation of matrix metalloprotease-2 levels by mechanical loading of three-dimensional mesenchymal stem cell constructs: impact on in vitro tube formation.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/pubmed/20486790>Tissue Eng Part A.</a></u> 2010 Oct;16(10):3139-48. <br><br>D. Obradovic Wagner, C. Sieber, R. Bhushan, J. Börgermann, D. Graf, P. Knaus. <br> <b>BMPs: From bone to body morphogenetic proteins.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/pubmed/20124549>Sci. Signal.</a></u>2010 Feb 2;3(107):mr1. <br><br> <b>[2009]</b> <br><br>Sieber C, Kopf J, Hiepen C, Knaus P.<br> <b>Recent advances in BMP receptor signaling.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/pubmed/19897402?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1>Cytokine Growth Factor Rev.</a></u> 2009 Oct-Dec;20(5-6):343-55. <br><br>Hauburger A, von Einem S, Schwaerzer GK, Buttstedt A, Zebisch M, Schräml M, Hortschansky P, Knaus P, Schwarz E.<br> <b>The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/pubmed/19804412?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2>FEBS J.</a></u> 2009 Nov;276(21):6386-98. <br><br>Schwappacher R, Weiske J, Heining E, Ezerski V, Marom B, Henis YI, Huber O, Knaus P.<br> <b>Novel crosstalk to BMP signalling: cGMP-dependent kinase I modulates BMP receptor and Smad activity.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/pubmed/19424179?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum>EMBO J.</a></u> 2009 Jun 3;28(11):1537-50. <br><br>Bengtsson L, Schwappacher R, Roth M, Boergermann JH, Hassel S, Knaus P.<br> <b>PP2A regulates BMP signalling by interacting with BMP receptor complexes and by dephosphorylating both the C-terminus and the linker region of Smad1.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/pubmed/19339557?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum>J Cell Sci.</a></u> 2009 Apr 15;122(Pt 8):1248-57. <br><br>Sammar M, Sieber C, Knaus P.<br> <b>Biochemical and functional characterization of the Ror2/BRIb receptor complex.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/pubmed/19135982?ordinalpos=13&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum>Biochem Biophys Res Commun.</a></u> 2009 Mar 27;381(1):1-6. Epub 2009 Jan 9. <br><br><b>[2008]</b> <br><br> Christina Sieber, Gerburg K. Schwaerzer and Petra Knaus<br> <b>Book: Bone Morphogenetic Proteins: From Local to Systemic Therapeutics<br> Chapter: BMP signaling is fine tuned on multiple levels</b><br> <u><a href=http://www.springerlink.com/content/p17v133518365620/?p=1d7833e78ff54568bb55e9080f9382af&pi=5 target=new>Progress in Inflammation Research</a></u> ISBN 978-3-7643-8551-4 (Print) 978-3-7643-8552-1 (Online) <br><br> Zavala-Góngora R, Derrer B, Gelmedin V, Knaus P, Brehm K.<br> <b>Molecular characterisation of a second structurally unusual AR-Smad without an MH1 domain and a Smad4 orthologue from Echinococcus multilocularis.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/pubmed/17845804?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum target=new>Int J Parasitol.</a></u> 2008 Feb;38(2):161-76. <br><br> <b>[2007]</b> <br><br> Morty RE, Nejman B, Kwapiszewska G, Hecker M, Zakrzewicz A, Kouri FM, Peters DM, Dumitrascu R, Seeger W, Knaus P, Schermuly RT, Eickelberg O.<br> <b>Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17347486&query_hl=5&itool=pubmed_docsum traget=new>Arterioscler Thromb Vasc Biol.</a></u> 2007 May;27(5):1072-8. <br><br>Parker WL, Finnson KW, Soe-Lin H, Knaus P, Philip A.<br> <b>Expression and function of TbetaRII-B, a variant of the type II TGF-beta receptor, in human chondrocytes.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17175180&query_hl=5&itool=pubmed_docsum target=new>Osteoarthritis Cartilage.</a></u> 2007 Apr;15(4):442-53. <br><br> <b>[2006]</b> <br><br>Lehmann K, Seemann P, Boergermann J, Morin G, Reif S, Knaus P, Mundlos S.<br> <b>A novel R486Q mutation in BMPR1B resulting in either a brachydactyly type C/symphalangism-like phenotype or brachydactyly type A2.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16957682&query_hl=1&itool=pubmed_docsum target=new>Eur J Hum Genet.</a></u> 2006 Dec;14(12):1248-54. <br><br>Hartung A, Bitton-Worms K, Rechtman MM, Wenzel V, Borgermann JH, Hassel S, Henis YI, Knaus P.<br> <b>Different routes of BMP receptor endocytosis influence BMP signaling.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/pubmed/16923969?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum target=new>Mol Cell Biol.</a></u> 2006 Oct;26(20):7791-805. <br><br>Hartung A, Sieber C, Knaus P.<br> <b>Yin and Yang in BMP signaling: Impact on the pathology of diseases and potential for tissue regeneration.</b><br> <u><a href=http://www3.interscience.wiley.com/journal/113344209/abstract?CRETRY=1&SRETRY=0 target=new>Signal Transduction</a></u> 2006 Sep;6(5):297-99. <br><br>Sieber C, Ploeger F, Schwappacher R, Bechthold R, Hanke M, Kawai S, Muraki Y, Katsuura M, Kimura M, Mouler Rechtman M, Henis YI, Pohl J, Knaus P.<br> <b>Monomeric and dimeric GDF-5 show same type I receptor binding and oligomerization capability and same biological activity</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16606344&query_hl=4&itool=pubmed_docsum target=new> Biol. Chem.</a></u> 2006 Apr;387(4):451-60. <br><br>Meyer-Ter-Vehn T, Gebhardt S, Sebald W, Buttmann M, Grehn F, Schlunck G, Knaus P.<br> <b>p38 Inhibitors Prevent TGF-{beta}-Induced Myofibroblast Transdifferentiation in Human Tenon Fibroblasts.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16565385&query_hl=30&itool=pubmed_docsum target=new>Invest Ophthalmol Vis Sci.</a></u> 2006 Apr;47(4):1500-9. <br><br>Zavala-Góngora R, Kroner A, Bernthaler P, Knaus P, Brehm K.<br> <b>A member of the transforming growth factor-beta receptor family from Echinococcus multilocularis is activated by human bone morphogenetic protein 2.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16434111&itool=pubmed_DocSum target=new> Mol Biochem Parasitol.</a></u> 2006 Apr;146(2):265-271. <br><br>Klein J, Ju W, Heyer J, Wittek B, Haneke T, Knaus P, Kucherlapati R, Bottinger EP, Nitschke L, Kneitz B.<br> <b>B Cell-Specific Deficiency for Smad2 In Vivo Leads to Defects in TGF-beta-Directed IgA Switching and Changes in B Cell Fate.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16455997&query_hl=8&itool=pubmed_docsum target=new>J Immunol.</a></u> 2006 Feb 15;176(4):2389-96. <br><br> <b>[2005]</b> <br><br>Hassel S, Yakymovych M, Hellman U, Ronnstrand L, Knaus P, Souchelnytskyi S.<br> <b>Interaction and functional cooperation between the serine/threonine kinase bone morphogenetic protein type II receptor with the tyrosine kinase stem cell factor receptor.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16155937 target=new> J Cell Physiol.</a></u> 2006 Feb;206(2):457-67. <br><br>Seemann P, Schwappacher R, Kjaer KW, Krakow D, Lehmann K, Dawson K, Stricker S, Pohl J, Ploger F, Staub E, Nickel J, Sebald W, Knaus P, Mundlos S.<br> <b>Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16127465 target=new>J Clin Invest.</a></u> 2005 Sep 1;115(9):2373-2381. <br><br> <b>[2004]</b> <br><br>Marei Sammar, Sigmar Stricker, Georg C. Schwabe, Christina Sieber, Anke Hartung, Michael Hanke, Isao Oishi, Jens Pohl, Yasuhiro Minami, Walter Sebald, Stefan Mundlos and Petra Knaus<br> <b>Modulation of GDF5/BRI-b signalling through interaction with the tyrosine kinase receptor Ror2</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15569154 target=new>Genes to Cells</a></u> 2004 Dec;9(12):1227-38. <br><br>Sylke Hassel, Annegret Eichner, Mariya Yakymovych, Ulf Hellman, Petra Knaus and Serhiy Souchelnytskyi<br> <b>Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15188402 target=new>Proteomics</a></u> 2004, 4, 1346 1358. <br><br>Lutz M, Krieglstein K, Schmitt S, ten Dijke P, Sebald W, Wizenmann A, Knaus P.<br> <b>Nerve growth factor mediates activation of the Smad pathway in PC12 cells.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/utils/lofref.fcgi?PrId=3046&uid=15009204&db=pubmed&url=http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=0014-2956&date=2004&volume=271&issue=5&spage=920 target=new>Eur J Biochem.</a></u> 2004, 271(5):920-31. <br><br>Nohe A, Keating E, Knaus P, Petersen NO.<br> <b>Signal transduction of bone morphogenetic protein receptors.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=14687659&query_hl=23&itool=pubmed_docsum target=new>Cell Signal.</a></u> 2004 Mar;16(3):291-9. <br><br>Schiemann W, Rotzer D, Pfeifer W, Levi E, Wang Z, Petrogiannis-Haliotis T, Rai K, Knaus P, Kadin M.<br> <b>TGF-ß-resistant B cells from Chronic Lymphocytic Leukemia patients contain recurrent mutations in the signal sequence of the Type I TGF-ß Receptor.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15041079&query_hl=12&itool=pubmed_docsum target=new>Cancer Detect Prev.</a></u> 2004;28(1):57-64. <br><br> <b>[2003]</b> <br><br>Lehmann K, Seemann P, Stricker S, Sammar M, Meyer B, Suring K, Majewski F, Tinschert S, Grzeschik KH, Muller D, Knaus P, Nurnberg P, Mundlos S.<br> <b>Mutations in BMPR1B cause Brachydactyly type A2.</b> <br><u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=14523231&query_hl=29&itool=pubmed_docsum target=new>Proc Natl Acad Sci. USA</a></u> 2003 Oct 14;100(21):12277-82. <br><br>Zavala-Góngora, R, Kroner A., Wittek, B. Knaus P, Brehm B.<br> <b>Identification and characterisation of two distinct Smad proteins from the fox-tapeworm Echinococcus multilocularis.</b> <br><u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=14636682&query_hl=26&itool=pubmed_docsum target=new>Int J Parasitology </a></u> 2003 Dec;33(14):1665-77.Click here to read <br><br>Gekle M, Knaus P, Nielsen R, Mildenberger S, Freudinger R, Wohlfarth V, Sauvant C, Christensen EI.<br> <b>Transforming growth factor-beta1 reduces megalin- and cubilin-mediated endocytosis of albumin in proximal-tubule-derived opossum kidney cells.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=14561830&query_hl=26&itool=pubmed_docsum target=new>J Physiol.</a></u> 2003 Oct 15;552(Pt 2):471-81. <br><br>Nohe A, Keating E, Underhill TM, Knaus P, Petersen NO.<br> <b>Effect of Distribution and Clustering of BMP receptors on the activation of signaling pathways.</b> <br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12829744&query_hl=23&itool=pubmed_docsum target=new>J Cell Sci.</a></u> 2003 Aug 15;116(Pt 16):3277-84. <br><br>Hassel S, Schmitt S, Hartung A, Roth M, Nohe A, Petersen N, Ehrlich M, Henis YI, Sebald W, Knaus P.<br> <b>Initiation of Smad-dependent and Smad-independent Signaling via Distinct BMP-receptor complexes.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12925609&query_hl=8&itool=pubmed_docsum target=new>J Bone Joint Surg Am.</a></u> 2003;85-A Suppl 3:44-51. <br><br>Pohl F, Hassel S, Nohe A, Flentje M, Knaus P, Sebald W, Koelbl O.<br> <b>Radiation induced suppression of the BMP-2 (bone morphogenetic protein) signal transduction pathway in the pluripotent, mesenchymal cell line C2C12: an  in vitro model for prevention of heterotopic ossification by radiotherapy.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12600237&query_hl=21&itool=pubmed_docsum target=new>Radiat Res.</a></u> 2003 Mar;159(3):345-50.Click here to read <br><br> <b>[2002]</b> <br><br>Lutz M, Knaus P.<br> <b>Integration of the TGF-ß pathway into the cellular signalling network.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12359303&query_hl=19&itool=pubmed_docsum target=new>Cell Signal.</a></u>, 2002 Dec;14(12):977-88. <br><br>Feldmann K, Sebald W, Knaus P.<br> <b>Resistance to TGF-ß1 mediated growth inhibition correlates with sustained Smad2 phosphorylation in primary murine splenocytes.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11981827&query_hl=15&itool=pubmed_docsum target=new>Eur. J. Immunol.</a></u> 2002 May;32(5):1393-402. <br><br>Nohe A, Hassel S, Ehrlich M, Neubauer F, Sebald W, Henis YI, Knaus P.<br> <b>The mode of BMP receptor oligomerization determines different BMP-2 signaling pathways.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11714695&query_hl=15&itool=pubmed_docsum target=new>J Biol Chem.</a></u> 2002 Feb 15;277(7):5330-8. <br><br> <b>[2001]</b> <br><br>Koelbl O, Knaus P, Pohl F, Flentje M, Sebald W.<br> <b>Radiation induced reduction of BMP-induced proteoglycansynthesis in a embryonal, mesenchymal tissue equivalent using the chicken  limb bud test.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11544906&query_hl=15&itool=pubmed_docsum target=new>Strahlenther Onkol.</a></u> 2001 Aug;177(8):432-6. <br><br>Knaus P, Sebald W.<br> <b>Cooperativity of binding epitopes and receptor chains in the BMP/TGFß superfamily.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11592400&query_hl=15&itool=pubmed_docsum target=new>Biol Chem.</a></u> 2001 Aug;382(8):1189-95. <br><br>Rotzer D, Roth M, Lutz M, Lindemann D, Sebald W, Knaus P.<br> <b>Type III TGF-ß Receptor independent signaling of TGF-ß2 via TßRII-B, an alternative spliced TGF-ß Type II Receptor.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11157754&query_hl=12&itool=pubmed_docsum target=new>EMBO J.</a></u> 2001 Feb 1;20(3):480-90. <br><br> <b>[2000]</b> <br><br>Gilboa L, Nohe A, Geissendorfer T, Sebald W, Henis YI, Knaus P.<br> <b>Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=10712517&query_hl=8&itool=pubmed_docsum target=new>Mol Biol Cell.</a></u> 2000 Mar;11(3):1023-35. <br><br> <b>[1997]</b> <br><br>DeCoteau JF, Knaus PI, Yankelev H, Reis MD, Lowsky R, Lodish HF, Kadin ME.<br> <b>Loss of functional cell surface transforming growth factor-ß (TGF-ß) type I receptor correlates with insensitivity to TGF-ß in chronic lymphocytic leukemia.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=9159168&query_hl=3&itool=pubmed_docsum target=new>Proc Natl Acad. Sci. USA</a></u> 1997 May 27;94(11):5877-81. <br><br> <b>[1996]</b> <br><br>Knaus PI, Lindemann D, DeCoteau JF, Perlman R, Yankelev H, Hille M, Kadin ME, Lodish HF.<br> <b>A dominant inhibitory mutant of the type II TGF-ß receptor in the malignant progression of a cutaneous T-cell lymphoma.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=8668164&query_hl=3&itool=pubmed_docsum target=new>Mol Cell Biol.</a></u> 1996 Jul;16(7):3480-9. <br><br> <b>[1995]</b> <br><br>Lin HY, Moustakas A, Knaus P, Wells R, Henis YI, Lodish H.<br> <b>The soluble exoplasmic domain of the Type II Transforming Growth Factor (TGF)-ß Receptor.</b><br> <u><a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=7852346&query_hl=3&itool=pubmed_docsum target=new>J. of Biol. Chem.</a></u> 1995 Feb 10;270(6):2747-54. <br><br> <b>[1993]</b> <br><br>Knaus P, Lodish HF.<br> <b>Receptors for Transforming Growth Factor-ß (TGF-ß). Guidebook to Cytokines and their Receptors.</b><br> Editor Nicos A. Nicola. 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